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Web Pages
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  NCBI BLAST http://www.ncbi.nlm.nih.gov/BLAST/
BLAST (Basic Local Alignment Search Tool) is a set of similarity search programs designed to explore all of the available sequence databases regardless of whether the query is protein or DNA.
  Cytoscape http://www.cytoscape.org/
Open source bioinformatics software platform for visualizing molecular interaction networks and integrating these interactions with gene expression profiles and other state data. It is also a general platform for complex network analysis and visualization.
  http://hmmer.janelia.org/ http://hmmer.janelia.org/
Profiles protein sequence data using hidden Markov models of a statistical descriptions of a sequence family's consensus. HMMER is a freely distributable implementation of profile HMM software for protein sequence analysis.
  WU-BLAST http://blast.wustl.edu/
The Washington University improved version of BLAST. Free for academic users.
  http://www.mbio.ncsu.edu/BioEdit/bioedit.html http://www.mbio.ncsu.edu/BioEdit/bioedit.html
Free Windows biological sequence alignment editor.
  http://emboss.sourceforge.net/ http://emboss.sourceforge.net/
The European Molecular Biology Open Software Suite. An open source project started by the EMBnet community in order to replace proprietary systems like GCG.
  Phrap/Consed http://www.phrap.org/
DNA sequence assembler and finishing tools from the UW Genome Center.
  Premier Biosoft International http://www.premierbiosoft.com/
Developers of software for real time PCR primer design, TaqMan, molecular beacons, SYBR green, FRET, DNA microarray analysis, restriction cloning, plasmid maps, gateway cloning, protein interaction network and functional genomics.
  CodonCode Corporation http://www.codoncode.com/
Offers CodonCode Aligner, a DNA sequence assembly, sequence alignment, contig editing and mutation detection software for Windows and Mac OS X.
  The ARB Project http://www.arb-home.de
A free sequence database application for Unix. It includes a sequence editor, several sequence aligners, phylogeny reconstruction tools, probe/primer search and generation, genome annotation and visualization. In addition to the integrated user-interface the ARB database can be accessed using Perl or C.
  sys-bio.org http://sbw.kgi.edu/
Software for simulating metabolic, signal and genetic networks. Home of SBW, Jarnac, JDesigner and winSCAMP.
  Expression Profiler http://www.ebi.ac.uk/expressionprofiler/
An open, extensible web-based collaborative platform for microarray gene expression, sequence and PPI data analysis, exposing distinct chainable components for clustering, pattern discovery, statistics, machine-learning algorithms and visualization.
  http://bioinformatics.org/sewer/ http://bioinformatics.org/sewer/
An integrated portal for common web-based bioinformatics services. Built in Javascript as a standalone browser application.
  http://www.charite.de/bioinf/strap http://www.charite.de/bioinf/strap
Software supports the analysis of hundreds of proteins and integrates aa sequence, secondary structure, 3D-structure and genomic- and mRNA-sequence, and residue annotation.
  Geneious http://www.geneious.com
This research software is designed for biologists and not computer scientists. It combines all the major DNA and protein sequence analysis tools into one software solution.
  http://align.bmr.kyushu-u.ac.jp/mafft/online/server/ http://align.bmr.kyushu-u.ac.jp/mafft/online/server/
Multiple sequence alignment program for linux and other unix-like operating systems. Offers a range of multiple alignment strategies.
  msa.cgb.ki.se http://msa.cgb.ki.se/cgi-bin/msa.cgi
Open source software developed by Timo Lassmann for multiple sequence alignment, including Kalign, Kalignvu and Mumsa.
  Meta-MEME http://metameme.sdsc.edu/
Software toolkit for building and using motif-based hidden Markov models of DNA and proteins - from the Univ. of California-San Diego.
  Unipro UGENE: Integrated Bioinformatics Tools http://ugene.unipro.ru
Free cross-platform bioinformatics software package for DNA and protein sequence analysis.
  Tandem Repeats Finder http://tandem.bu.edu/trf/trf.html
Locates and displays tandem repeats in DNA sequences.
  http://www.acaclone.com http://www.acaclone.com
Freeware DNA cloning, analysis and visualization software.
  Seqtools http://www.seqtools.dk
Commercial Windows software for batch handling and analysis of nucleotide and protein sequences.
  http://www.bcgsc.ca/gc/bomge/sockeye/ http://www.bcgsc.ca/gc/bomge/sockeye/
3D visualisation platform for Comparative Genomics visualisation.
  http://www.ebi.ac.uk/Tools/fasta/ http://www.ebi.ac.uk/Tools/fasta/
William Pearson's package for fast sequence comparison tools.
  http://www.ebi.ac.uk/~lenov/meltinghome.html http://www.ebi.ac.uk/~lenov/meltinghome.html
Computes, for a nucleic acid duplex, the enthalpy, the entropy and the melting temperature of the helix-coil transitions.
  http://sfold.wadsworth.org/index.pl http://sfold.wadsworth.org/index.pl
Predicts probable RNA secondary structures, assesses target accessibility, and provides tools for the rational design of RNA-targeting nucleic acids. The web server version is free for academic use.
  http://cbrg.inf.ethz.ch/Darwin/index.html http://cbrg.inf.ethz.ch/Darwin/index.html
An interactive tool for peptide and nucleotide sequence analysis.
  http://biomaj.genouest.org http://biomaj.genouest.org
Workflow engine dedicated to bio-data synchronization and processing.
  GeneSifter http://www.genesifter.net
Provides complete systems for data-intensive genetic analysis applications like microarrays and next gen sequencing-based transcription. From Geospiza, Seattle, USA.
  limmaGUI http://bioinf.wehi.edu.au/limmaGUI/index.html
A graphical user interface for linear modelling of cDNA and oligonucleotide microarray data to identify differentially expressed genes.
  http://gel.ahabs.wisc.edu/mauve/ http://gel.ahabs.wisc.edu/mauve/
Free software for constructing global alignments of multiple rearranged genomes. The visualization environment displays sequence similarity profiles and annotated sequence features.
  NEXML: Phylogenetic Data in xml http://www.nexml.org
Exchange standard for representing phylogenetic data, inspired by the commonly used NEXUS format but more robust and easier to process.
  ARCiB -- Accessible Retired Computers in Biology http://arcib.dowling.edu/
NSF supported project to make old computers accessible to new software in bioinformatics. Provides transitional and supplemental support, especially in structural biology, for software packages on various platforms.
  http://www.lynnon.com http://www.lynnon.com
Commercial software for DNA and Protein sequence analysis and manipulation. Available for Windows and Mac OS X.
  JAligner http://jaligner.sourceforge.net/
Java implementation of the dynamic programming algorithm Smith-Waterman for biological local pairwise sequence alignment.
  http://chevreux.org/projects_mira.html http://chevreux.org/projects_mira.html
A sequence assembly suite with SNP detection for "hard" projects.
  Nano+Bio-Centre http://nbc3.biologie.uni-kl.de
Offers a range of free software tools for annotating an entire genome, assembling sequences, gap closing and analysis of microarrays.
  MaGe (Magnifying Genomes) - Microbial genome Annotation System http://www.genoscope.cns.fr/agc/mage/
The MaGe system offers a set of graphical interfaces which allow biologist to perform relevant expert annotation of microbial genomes.
  Sequence Analysis http://www.informagen.com/SA/
A freeware Java application that does many standard types of DNA and protein sequence analysis tasks.
  http://www.genome.washington.edu/UWGC/analysistools/Phred.cfm http://www.genome.washington.edu/UWGC/analysistools/Phred.cfm
A widely-used program for base calling DNA sequencing trace files. Source code available and free for non-commercial users.
  DNA Baser http://www.dnabaser.com/
Sequence assembly software package including a free tool for merging multiple FASTA files into a single FASTA file.
  INCA - INteractive Codon Analysis http://www.bioinfo-hr.org/inca
Windows software that computes and charts codon and amino acid frequencies in whole genomes. Produces fully customizable scatter plots with the possibility to export graphics or text files for further analysis. Free for academic users.
  http://mozart.bio.neu.edu/friend/friend.html http://mozart.bio.neu.edu/friend/friend.html
An integrated multiple structure visualization and multiple sequence alignment application. Available for Windows, Linux.
  http://bioinformatics.org/annhyb/ http://bioinformatics.org/annhyb/
Free software for working with and managing nucleotide sequences in multiple formats. Features include sequence annotation, restriction analysis, pattern searching, retrieval from servers. Released under GNU Public Licence.
  PhyloSort http://phylosort.sourceforge.net/
A Java tool to sort phylogenetic trees by searching for user-specified subtrees that contain a monophyletic group of interest defined by operational taxonomic units.
  http://www.helsinki.fi/project/ritvos/GoCore/ http://www.helsinki.fi/project/ritvos/GoCore/
GoCore is a free Excel based tool for protein sequence alignment, comparisons and functional predictions in a simple, visually appealing, manner.
  Biomax BioXM Knowledge Management Environment http://www.biomax.com/products/bioxm.php
Project-centered, distributed software platform that provides a central inventory of information and knowledge. Users create, manage and visualize scientific models as an extendible network of interrelated concepts.
  http://bioinf.dms.med.uniroma1.it/JSTRING/ http://bioinf.dms.med.uniroma1.it/JSTRING/
Java program for searching Tandem Repeats (TR) in a DNA sequence. It shows the results also in a graphical format.
  http://www.bioafrica.net/GDElinux/index.html http://www.bioafrica.net/GDElinux/index.html
An integrated linux environment for bioinformatics and evolutionary analysis based on the Genetic Data Environment (GDE). Contains binaries for Linux and Mac OS X, documentation, screenshots, references, and organism specific interfaces.
  CentiBiN: Centralities in Biological Networks http://centibin.ipk-gatersleben.de/
Application for the calculation and visualization of centralities for biological networks.
  Bioinformatics Tools in Haskell http://malde.org/~ketil/
A bioinformatics library implemented in Haskell, including various utilities based on it.
  Genome-tools Web Interface http://sourceforge.net/projects/genome-tools/
Genome-tools provides flexible tools and a simple API for genomic sequence processing on genomes published in the standard Genbank format.
  http://www.ariadnegenomics.com/products/medscan.html http://www.ariadnegenomics.com/products/medscan.html
Commercial Windows natural language processing software for the automated extraction of biological data from scientific literature.
  DNPTrapper http://dnptrapper.sourceforge.net/
A Linux assembly editing and visualization tool specifically designed for manual analysis and finishing of repeated regions.
  GeneRunner http://www.generunner.net
A fairly old Windows sequence analysis tool for everyday lab use. Formerly a commercial product.
  http://compbio.charite.de/index.php/gsuffix.html http://compbio.charite.de/index.php/gsuffix.html
C-language implementations of generalized suffix-based algorithms useful for searching for string patterns in sets of input strings and is released under the terms of the LGPL license.
  XDigitize http://www.molgen.mpg.de/~xdigitise/
A Linux/Unix visualization software system for evaluation of hybridisation experiments.
  Genespotter http://www.genespotter.de
Commercial Windows software for analyzing biochip image data.
  http://www.lightwave-scientific.com/Resources/biOpen.pdf http://www.lightwave-scientific.com/Resources/biOpen.pdf
Commercial Mac OS X sequence analysis and structure visualization software.
  APBioKnoppix http://opensource.nus.edu.sg/wiki/index.php/APBioKnoppix
Knoppix based bioinformatics software tools. Bootable from CD.
  KoriBlast http://www.korilog.com/products/improving-NCBI-BLAST.php
Commercial graphical software for Blast searches.
  ADF MAGE-ML http://adfconverter.sourceforge.net/
Open source Java software for checking and conversion of MicroArray Array Design data file (ADF -Array Design File- MAGE-ML).
  Biochemfusion: Enabling Biochemformatics http://www.biochemfusion.com
Software for working with post-translationally or chemically modified peptides and proteins including proteins as both sequences and chemical structures.
  http://gints.free.fr/english/eng_whatsAbout.htm http://gints.free.fr/english/eng_whatsAbout.htm
Object-oriented regulation network simulator written in Java. Includes downloadable software and documentation. The site is in French and English.
  Bioinformatics Software Tools http://www.bio32.com
Provides access to a number of tools including biological databases, sequence allignment, analysis and manipulation tools and structural analysis tools. Also provides a glossary of bioinformatics terms.
  Automated Codon Usage Analysis Software http://www.bioinsilico.com/acua
ACUA is a freeware VB based interface for Insilico codon analysis. It provides nucleotide analysis, statistical codon analysis and positional nucleotide analysis. It presents the results in spreadsheets which can be utilized for further statistical analysis.
  RGBG Analyzer http://www.immunokin.com
Commercial software to analyses the red, green, blue, and gray color values of user-selected areas of images in gif, tiff, bmp, jpeg format. Windows 2000 and XP.
  http://www.caspur.it/~castri/STRING/index.htm http://www.caspur.it/~castri/STRING/index.htm
Search for Tandem Repeats IN Genomes. Includes C source code and examples.
  http://www.cs.uni.edu/~okane/source/MARBL/proc1.html http://www.cs.uni.edu/~okane/source/MARBL/proc1.html
MARBL is a free (GPL) system to index the text portions of GenBank and associated NLM abstracts. Based on Mumps and the MDH.
  AlmaKnowledgeServer http://www.timelogic.com/aks/index.html
Text mining tool for genomics, proteomics platforms and drug discovery.
  Biological Concept Diagram Editor http://arrayanalysis.mbni.med.umich.edu/draw/
A tool designed for efficient knowledge and data capture from electronic resources for sharing, mining and presentation purposes.

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