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Cambridge Healthtech Institute - http://www.healthtech.com/
CHI organizes RNAi-related conferences throughout the US and Europe, including therapeutics, pharmaceutics, drug development, target discovery, and biodefense. Provides biotechnology news and conferences information. |
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NANOPOLIS - http://www.nanopolis.net
Educational portal providing nanotechnology articles and multimedia courses in the multidisciplinary research areas. |
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The microRNA Registry - http://www.sanger.ac.uk/Software/Rfam/mirna/
Online resource provides a service for the assignment of miRNA gene names. Provides searchable database of published miRNA sequences. Includes data and research application information. |
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RNAi Mechanism Animation by Journal Nature - http://www.nature.com/focus/rnai/animations
An animation from Nature Publishing Group on the mechanism of RNA Interference (RNAi). |
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A TV Show on RNAi by PBS - http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html
NOVA scienceNOW TV program describes RNAi as a major breakthrough in gene therapy with enormous medical promise. Provides basic overview of RNAi technology, current therapeutic approaches, and interview with the experts in the field. Includes 15-minutes TV broadcast segment on RNAi. |
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Ordway Research Institute - http://www.ordwayresearch.org
Not-for-profit corporation with a mission to translate basic science observations into therapeutics. Provides research services including quantitation of endogenous levels of microRNAs and mRNAs from experimental samples. Includes information on research focus areas and technology development. |
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Wikipedia Article on RNAi - http://en.wikipedia.org/wiki/RNA_interference
Online article describing the basics of RNA Interference (RNAi) mechanism. |
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RNAi.net - http://www.rnai.net
Online resource offering information RNA interference and related issues: news, interviews, articles, techniques. |
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Pharmaceutical Discovery - http://www.pharmaceuticaldiscovery.com/
Peer-review online journal publishing articles on recent advances in life sciences research and drug discovery. Includes RNAi related news, overview of new technology, and research articles. |
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Nature web focus: RNAi - http://www.nature.com/nature/focus/rnai/index.html
Online review of RNA Interference biological phenomena. Includes citations of recent research publications, RNAi animations, and science news articles. |
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Oligonucleotide Therapeutic Society - http://www.myots.org/
Society host conferences on academia and industry-based research and development of oligonucleotide therapeutics: RNAi, antisense, and others. Provides society overview, publication materials, meetings, and contact information. |
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RNAi Gateway - http://www.biomedcentral.com/gateways/RNAi/
Web resource from BioMed Central. Provides RNA Interference (RNAi) research highlights, journal links, news, and meeting information. |
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RNAi Resource at Ambion - http://www.ambion.com/techlib/resources/RNAi/
Online RNA Interference (RNAi) resource. Provide scientific and technical support, information on microRNA and small interfering RNA application in gene expression research. |
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Nuclear Receptor Signaling Atlas - http://www.nursa.org/
Informational portal for researchers interested in nuclear receptor signaling. |
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TargetScan - http://genes.mit.edu/targetscan/
Online software provided by MIT for prediction of microRNA targets. Provides research data and online software for microRNA target identification and analysis. |
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DBTGR - Database of Tunicate Gene Regulation - http://dbtgr.hgc.jp
Gene expression database of tunicates. Provides the descriptions of 12 transcription factors and 140 promoters. |
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Journal of RNAi and Gene Silencing - http://www.libpubmedia.co.uk/RNAiJ/RNAiJHome.htm
Publishes peer-reviewed articles addressing the biology and application of RNA interference and gene silencing. Includes information about journal aims and scope, publication policies, and manuscript submission. Provides online access to journal articles. |
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Silencing Genomes - http://silencinggenomes.org/
Portal about genome-wide applications of RNAi by Cold Spring Harbor Laboratory. |
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RNA Interference - http://hhmi.org/biointeractive/rna/rnai/
Interactive online resource from Howard Hughes Medical Institute. Presents RNAi mechanism and overview of key scientific findings. |
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RNAi Database - http://www.rnai.org/
Includes all siRNA from C. elegans including assay, resulting phenotypes, dsRNA target location. Database provides Gene/Protein or Phenotype search options. |
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Rosetta Genomics - http://www.rosettagenomics.com/
Israel-based microRNA genomics company, develops bioinformatic tools for miRNA gene detection approach. |
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The siRNA User Guide - http://www.rockefeller.edu/labheads/tuschl/sirna.html
Online guide for performing RNAi experiments using synthetic siRNA molecules. By Tuschl Lab at Rockefeller University. |
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Article on siRNA from Wikipedia - http://en.wikipedia.org/wiki/Small_interfering_RNA
Describes small interfering RNA (siRNA) function, structure, use in research, and potential application for therapy. |
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The RNAi Cure - http://www.pbs.org/wgbh/nova/sciencenow/3210/02-cure.html
A NOVA ScienceNOW science program by PBS feature the possible applications for RNAi therapy. Provides animations of key biological processes and mechanism of RNA Interference. |
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Induction of an interferon response by RNAi vectors in mammalian cells - http://www.nature.com/ng/journal/v34/n3/full/ng1173.html
Article from journal Nature Genetics about potential complications of use of RNAi vector-based technology for therapeutics. |
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Small RNAs: Delivering the future - http://www.nature.com/nature/journal/v450/n7172/full/4501117a.html
Article by journal Nature about development of RNAi therapeutics. |
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MicroRNA in Cancer - http://www.nature.com/nature/journal/v435/n7043/edsumm/e050609-16.html
Review of microRNA role in cancer by Nature journal. Provides full-length research papers and reviews. |
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SI RNA - Small Interference RNA Resources - http://www.si-rna.com
Online resource from Ion Channel Media Group. Provides news, publication links, and citations of the recent literature relevant to RNA Interference research. |
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RNA Interference at Journal Nature - http://www.nature.com/focus/rnai/
Focus RNA Interference - online resource publishing recent advances in RNAi field, and novel applications in Nature Cell Biology and Nature Reviews. |
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RNAi News - http://www.rnainews.com
Online resource for scientists, researchers, technologists, and executives engaged in RNA Interference, functional genomics, and drug discovery. Offers industry news, product reviews, and meetings information. |
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RNAi Resource at Macalester College - http://www.macalester.edu/~montgomery/RNAi.html
Informational resource, including RNAi mechanism, overview of current studies, and related research protocols. |
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Gene Silencing Mechanism - http://www.nature.com/nrg/journal/v2/n2/animation/nrg0201_110a_swf_MEDIA1.html
Animation of post transcriptional gene silencing or RNA Interference (RNAi) by Nature Reviews Genetics. |
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The RNAi Web - http://www.rnaiweb.com/
Online resource for RNA Interference (RNAi) technology. Offers overview of technology, references, and links on other RNAi-related web resources. |
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Article on RNAi by GNN - http://www.genomenewsnetwork.org/articles/06_02/hiv.shtml
Online article describing gene silencing mechanism and how RNAi can be used for HIV treatment. |
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RNAi@elegansNet - http://c.elegans.tripod.com/RNAi.htm
Directory on gene silencing by RNA interference (RNAi) literature and resources. |
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Article on RNAi by HOPES - http://www.stanford.edu/group/hopes/treatmts/pbuildup/h2.html
Online article describes basic mechanism of RNAi and how it can be applied for Huntington's disease treatment. |
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Oligoengine - http://www.oligoengine.com
Oligonucleotide design software for applications such as RNAi, DNA methylation, antisense, and genome arrays. |
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CnidBase: Cnidarian Evolutionary Genomics Database - http://cnidbase.bu.edu/
Cnidbase provides tools for researchers interested in studying gene expression of these organisms. Provides sequence BLAST tools, keyword search of genes and homologs, a literature scan, and several useful links. |
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The MIT/ICBP siRNA Database - http://web.mit.edu/sirna/
Online resource for researchers looking for experimentally validated siRNAs and shRNAs against target genes, with a focus on genes thought to be involved in cancer. |
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Protein Lounge - http://www.proteinlounge.com/sirna_home.asp
Provides database that contains targets against mRNA sequences throughout a variety of organisms. Includes gene search option, and disease-specific siRNA genes. |
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Drosophila RNAi Resource - http://www.sdbonline.org/fly/aignfam/rnaistuf.htm
Informational RNAi resource on studying drosophila genes and their roles in development by Society for Developmental Biology. |
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RNAi BioForum - http://www.protocol-online.org/forums/index.php?showforum=21
Online forum for siRNA, microRNA and RNAi methods discussion. |
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RNAi Meeting: From Target Discovery and Validation to Therapeutic Development - http://www.discoveryontarget.com/06-RNAI.asp
CHI's Discovery on Target RNAi meeting organized by Cambridge Healthtech Institute at Boston, Massachusetts, October 25-26, 2006. Meeting provides overview of various aspects in RNA Interference (RNAi) research, ranging from in vitro and in vivo drug discovery research to therapeutic applications. Online meeting information is available: plenary sessions, exhibits, and poster presentations. |
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RNAi Therapeutics: How Likely, How Soon? - http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0020028
Review article from PLoS Biology journal. Describes mechanism of RNA Interference, potential applications towards therapeutics, and current problems associated with delivery. |
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Navigating Journey of Genome to Medicine - http://www.iht.com/articles/2005/06/22/news/snturn.php
Review article on RNAi by International Herald Tribune. Provides an overview on RNA Interference discovery, current research efforts, and therapeutic potential. |
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Transcriptional Gene Silencing - http://www.scripps.edu/mem/rheum/morris/tgs/
Mechanisms of TGS by Kevin Morris laboratory. Includes description of HIV research performed using lentiviral vector gene therapy and RNAi mediated gene silencing. |
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RNAi Transfection Resource - http://cell-transfection.blogspot.com/
Review of transfection techniques such as electroporation, denrimers and lipids that are used for transfection of DNA, RNA, and siRNA. Includes information on optimized cell type specific transfection systems. |
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The RNAi vs. HIV - http://myweb.dal.ca/tbaptist/rnai/
Reviews the use of this therapy in fighting HIV. Includes mechanism, difficulties, terms, and featured experiments. |
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microRNA and Cancer Therapeutics - https://webspace.utexas.edu/do376/index.html
Online review of microRNA application for potential therapy of cancer by Dmitriy Ovcharenko. |
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Genetic Diversity - http://genetics.nbii.gov
Provides educational modules covering such parts of biology as genetics, cell biology, and gene expression. |
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Focus Areas: RNAi from Invitrogen - http://www.invitrogen.com/content.cfm?pageid=10062
Educational and product support page. Includes RNAi overview, history, and research suggestions for gene silencing experiments. |
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Second Annual Meeting of the Oligonucleotide Therapeutics Society - http://www.nyas.org/events/eventDetail.asp?eventID=5753&date=10/19/2006
Yearly conference organized by New York Academy of Sciences. Scientists from industry and academia meet to discuss use of oligonucleotide-based gene-silencing techniques for development of innovative therapeutics. Includes information about conference registration, preliminary program, and abstract submission. |
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InFocus RNAi Web Broadcast by Bio.com - http://www.bio.com/newsfeatures/infocus.jhtml?infocusId=1200002&realmId=
Review of RNAi advances, technologies and applications. Bio.com provides an online RNAi technology-focused webcast, experts in the field discuss new insights into the regulation of gene expression by RNAi. |
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SBS Conference - http://www.sbsonline.org/sbscon/2005/index.php
The Society for Biomolecular Screening holds a conference on high-throughput RNAi screening approach using siRNA/shRNA libraries on September 11-15, 2005. |